The fibronectin synergy site re-enforces cell adhesion and mediates a crosstalk between integrin classes

Fibronectin (FN), a major extracellular matrix component, enables integrin-mediated cell adhesion via binding of α5β1, αIIbβ3 and αv-class integrins to an RGD-motif. An additional linkage for α5 and αIIb is the synergy site located in close proximity to the RGD motif. We report that mice with a dysf...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Benito-Jardón, Maria, Klapproth, Sarah, Gimeno-LLuch, Irene, Petzold, Tobias, Bharadwaj, Mitasha, Müller, Daniel J, Zuchtriegel, Gabriele, Reichel, Christoph A, Costell, Mercedes
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2017
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5279944/
https://ncbi.nlm.nih.gov/pubmed/28092265
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.22264
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