α5β1 Integrin-Mediated Adhesion to Fibronectin Is Required for Axis Elongation and Somitogenesis in Mice

The arginine-glycine-aspartate (RGD) motif in fibronectin (FN) represents the major binding site for α5β1 and αvβ3 integrins. Mice lacking a functional RGD motif in FN (FN(RGE/RGE)) or α5 integrin develop identical phenotypes characterized by embryonic lethality and a severely shortened posterior tr...

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Detaylı Bibliyografya
Asıl Yazarlar: Girós, Amparo, Grgur, Katja, Gossler, Achim, Costell, Mercedes
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2011
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3142108/
https://ncbi.nlm.nih.gov/pubmed/21799763
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0022002
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