Insulin differentially affects the distribution kinetics of amyloid beta 40 and 42 in plasma and brain

Impaired brain clearance of amyloid-beta peptides (Aβ) 40 and 42 across the blood–brain barrier (BBB) is believed to be one of the pathways responsible for Alzheimer’s disease (AD) pathogenesis. Hyperinsulinemia prevalent in type II diabetes was shown to damage cerebral vasculature and increase Aβ a...

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Bibliografiska uppgifter
I publikationen:J Cereb Blood Flow Metab
Huvudupphovsmän: Swaminathan, Suresh Kumar, Ahlschwede, Kristen M, Sarma, Vidur, Curran, Geoffry L, Omtri, Rajesh S, Decklever, Teresa, Lowe, Val J, Poduslo, Joseph F, Kandimalla, Karunya K
Materialtyp: Artigo
Språk:Inglês
Publicerad: SAGE Publications 2017
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Original Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5987944/
https://ncbi.nlm.nih.gov/pubmed/28569090
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/0271678X17709709
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