High-Density Lipoprotein Mimetic Peptide 4F Efficiently Crosses the Blood-Brain Barrier and Modulates Amyloid-β Distribution between Brain and Plasma

Treatments to elevate high-density lipoprotein (HDL) levels in plasma have decreased cerebrovascular amyloid -β (Aβ) deposition and mitigated cognitive decline in Alzheimer disease (AD) transgenic mice. Since the major protein component of HDL particles, apolipoprotein A-I (ApoA-I), has very low per...

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Foilsithe in:J Pharmacol Exp Ther
Main Authors: Swaminathan, Suresh K., Zhou, Andrew L., Ahlschwede, Kristen M., Curran, Geoffry L., Lowe, Val J., Li, Ling, Kandimalla, Karunya K.
Formáid: Artigo
Teanga:Inglês
Foilsithe: The American Society for Pharmacology and Experimental Therapeutics 2020
Ábhair:
Metabolism, Transport, and Pharmacogenomics
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7589947/
https://ncbi.nlm.nih.gov/pubmed/32778535
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.120.265876
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