Traffic Jam at the Blood Brain Barrier Promotes Greater Accumulation of Alzheimer’s Disease Amyloid-β Proteins in the Cerebral Vasculature

Amyloid-β (Aβ) deposition in the brain vasculature results in cerebral amyloid angiopathy (CAA), which occurs in about 80% of Alzheimer’s disease (AD) patients. While Aβ42 predominates parenchymal amyloid plaques in AD brain, Aβ40 is prevalent in the cerebrovascular amyloid. Dutch mutation of Aβ40 (...

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Autors principals: Agyare, Edward K., Leonard, Sarah R., Curran, Geoffry L., Yu, Caroline C., Lowe, Val J., Paravastu, Anant K., Poduslo, Joseph F., Kandimalla, Karunya K.
Format: Artigo
Idioma:Inglês
Publicat: 2013
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3756545/
https://ncbi.nlm.nih.gov/pubmed/23249146
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/mp300352c
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