Development of a Smart Nano-vehicle to Target Cerebrovascular Amyloid Deposits and Brain Parenchymal Plaques Observed in Alzheimer's Disease and Cerebral Amyloid Angiopathy

PURPOSE: To design a smart nano-vehicle (SNV) capable of permeating the blood-brain barrier (BBB) to target cerebrovascular amyloid formed in both Alzheimer's disease (AD) and cerebrovascular amyloid angiopathy (CAA). METHODS: SNV consists of a chitosan polymeric core prepared through ionic gel...

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Detalhes bibliográficos
Main Authors: Agyare, Edward K., Curran, Geoffry L., Ramakrishnan, Muthu, Yu, Caroline C., Poduslo, Joseph F., Kandimalla, Karunya K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3766361/
https://ncbi.nlm.nih.gov/pubmed/18712585
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11095-008-9688-y
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