Selective Contrast Enhancement of Individual Alzheimer’s Disease Amyloid Plaques Using a Polyamine and Gd-DOTA Conjugated Antibody Fragment Against Fibrillar Aβ42 for Magnetic Resonance Molecular Imaging

PURPOSE: The lack of an in vivo diagnostic test for AD has prompted the targeting of amyloid plaques with diagnostic imaging probes. We describe the development of a contrast agent (CA) for magnetic resonance microimaging that utilizes the F(ab′)(2) fragment of a monoclonal antibody raised against f...

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Detalhes bibliográficos
Main Authors: Ramakrishnan, Muthu, Wengenack, Thomas M., Kandimalla, Karunya K., Curran, Geoffry L., Gilles, Emily J., Ramirez-Alvarado, Marina, Lin, Joseph, Garwood, Michael, Jack, Clifford R., Poduslo, Joseph F.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3766359/
https://ncbi.nlm.nih.gov/pubmed/18443900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11095-008-9600-9
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