Insulin differentially affects the distribution kinetics of amyloid beta 40 and 42 in plasma and brain

Impaired brain clearance of amyloid-beta peptides (Aβ) 40 and 42 across the blood–brain barrier (BBB) is believed to be one of the pathways responsible for Alzheimer’s disease (AD) pathogenesis. Hyperinsulinemia prevalent in type II diabetes was shown to damage cerebral vasculature and increase Aβ a...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Cereb Blood Flow Metab
Prif Awduron: Swaminathan, Suresh Kumar, Ahlschwede, Kristen M, Sarma, Vidur, Curran, Geoffry L, Omtri, Rajesh S, Decklever, Teresa, Lowe, Val J, Poduslo, Joseph F, Kandimalla, Karunya K
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: SAGE Publications 2017
Pynciau:
Original Articles
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5987944/
https://ncbi.nlm.nih.gov/pubmed/28569090
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/0271678X17709709
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