HH Domain of Alzheimer’s Disease Aβ Provides Structural Basis for Neuronal Binding in PC12 and Mouse Cortical/Hippocampal Neurons

A key question in understanding AD is whether extracellular Aβ deposition of parenchymal amyloid plaques or intraneuronal Aβ accumulation initiates the AD process. Amyloid precursor protein (APP) is endocytosed from the cell surface into endosomes where it is cleaved to produce soluble Aβ which is t...

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Detalhes bibliográficos
Main Authors: Poduslo, Joseph F., Gilles, Emily J., Ramakrishnan, Muthu, Howell, Kyle G., Wengenack, Thomas M., Curran, Geoffry L., Kandimalla, Karunya K.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2809098/
https://ncbi.nlm.nih.gov/pubmed/20098681
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0008813
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