Active and inactive β1 integrins segregate into distinct nanoclusters in focal adhesions

Integrins are the core constituents of cell–matrix adhesion complexes such as focal adhesions (FAs) and play key roles in physiology and disease. Integrins fluctuate between active and inactive conformations, yet whether the activity state influences the spatial organization of integrins within FAs...

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Publicado en:J Cell Biol
Autores principales: Spiess, Matthias, Hernandez-Varas, Pablo, Oddone, Anna, Olofsson, Helene, Blom, Hans, Waithe, Dominic, Lock, John G., Lakadamyali, Melike, Strömblad, Staffan
Formato: Artigo
Lenguaje:Inglês
Publicado: Rockefeller University Press 2018
Materias:
Research Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5987715/
https://ncbi.nlm.nih.gov/pubmed/29632027
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201707075
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