Active and inactive β1 integrins segregate into distinct nanoclusters in focal adhesions

Integrins are the core constituents of cell–matrix adhesion complexes such as focal adhesions (FAs) and play key roles in physiology and disease. Integrins fluctuate between active and inactive conformations, yet whether the activity state influences the spatial organization of integrins within FAs...

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Veröffentlicht in:J Cell Biol
Hauptverfasser: Spiess, Matthias, Hernandez-Varas, Pablo, Oddone, Anna, Olofsson, Helene, Blom, Hans, Waithe, Dominic, Lock, John G., Lakadamyali, Melike, Strömblad, Staffan
Format: Artigo
Sprache:Inglês
Veröffentlicht: Rockefeller University Press 2018
Schlagworte:
Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5987715/
https://ncbi.nlm.nih.gov/pubmed/29632027
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201707075
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