Canonical Wnt Signaling Ameliorates Aging of Intestinal Stem Cells

Although intestinal homeostasis is maintained by intestinal stem cells (ISCs), regeneration is impaired upon aging. Here, we first uncover changes in intestinal architecture, cell number, and cell composition upon aging. Second, we identify a decline in the regenerative capacity of ISCs upon aging b...

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Bibliografske podrobnosti
izdano v:Cell Rep
Main Authors: Nalapareddy, Kodandaramireddy, Nattamai, Kalpana J., Kumar, Rupali S., Karns, Rebekah, Wikenheiser-Brokamp, Kathryn A., Sampson, Leesa L., Mahe, Maxime M., Sundaram, Nambirajan, Yacyshyn, Mary-Beth, Yacyshyn, Bruce, Helmrath, Michael A., Zheng, Yi, Geiger, Hartmut
Format: Artigo
Jezik:Inglês
Izdano: 2017
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5987258/
https://ncbi.nlm.nih.gov/pubmed/28297666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.02.056
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