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Cracking the DNA code for V(D)J recombination
To initiate V(D)J recombination for generating the adaptive immune response of vertebrates, RAG1/2 recombinase cleaves DNA at a pair of recombination signal sequences, the 12- and 23-RSS. We have determined crystal and cryoEM structures of RAG1/2 with DNA in the pre-reaction and hairpin-forming comp...
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| 出版年: | Mol Cell |
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| 主要な著者: | , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2018
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5987255/ https://ncbi.nlm.nih.gov/pubmed/29628308 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2018.03.008 |
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