Luteolin attenuates Wnt signaling via upregulation of FZD6 to suppress prostate cancer stemness revealed by comparative proteomics

The mechanisms underlying luteolin-induced inhibition of prostate cancer (PCa) stemness have remained elusive. Here, we report that luteolin suppresses PCa stemness through Wnt signaling by upregulation of FZD6 (frizzled class receptor 6). Luteolin inhibits PCa cell proliferation, migration, self-re...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Han, Kun, Lang, Tingyuan, Zhang, Zhiqi, Zhang, Yi, Sun, Yongning, Shen, Zan, Beuerman, Roger W., Zhou, Lei, Min, Daliu
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5986741/
https://ncbi.nlm.nih.gov/pubmed/29867083
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-26761-2
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