Hydrophobicity of Lipid-Conjugated siRNAs Predicts Productive Loading to Small Extracellular Vesicles

Small extracellular vesicles (sEVs) show promise as natural nano-devices for delivery of therapeutic RNA, but efficient loading of therapeutic RNA remains a challenge. We have recently shown that the attachment of cholesterol to small interfering RNAs (siRNAs) enables efficient and productive loadin...

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Detalhes bibliográficos
Publicado no:Mol Ther
Main Authors: Biscans, Annabelle, Haraszti, Reka A., Echeverria, Dimas, Miller, Rachael, Didiot, Marie-Cecile, Nikan, Mehran, Roux, Loic, Aronin, Neil, Khvorova, Anastasia
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Gene & Cell Therapy 2018
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5986735/
https://ncbi.nlm.nih.gov/pubmed/29699940
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2018.03.019
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