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Transcriptional activation of p21(Waf1) contributes to suppression of HR by p53 in response to replication arrest induced by camptothecin
The inhibitory effect of p53 on homologous recombination (HR) is exerted through sequestration of replication protein A (RPA). Release of the p53/RPA complex in response to replication stress is crucially dependent on the phosphorylation status of both proteins and is required for efficient DNA repa...
Shranjeno v:
| izdano v: | Oncotarget |
|---|---|
| Main Authors: | , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Impact Journals LLC
2018
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5986631/ https://ncbi.nlm.nih.gov/pubmed/29875999 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.25172 |
| Oznake: |
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