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Transcriptional activation of p21(Waf1) contributes to suppression of HR by p53 in response to replication arrest induced by camptothecin
The inhibitory effect of p53 on homologous recombination (HR) is exerted through sequestration of replication protein A (RPA). Release of the p53/RPA complex in response to replication stress is crucially dependent on the phosphorylation status of both proteins and is required for efficient DNA repa...
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| Publicat a: | Oncotarget |
|---|---|
| Autors principals: | , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Impact Journals LLC
2018
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5986631/ https://ncbi.nlm.nih.gov/pubmed/29875999 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.25172 |
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