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Cooperative actions of p21(WAF)(1) and p53 induce Slug protein degradation and suppress cell invasion
How the p53 transcription factor/tumor suppressor inhibits cell invasion is poorly understood. We demonstrate that this function of p53 requires its direct interaction with p21(WAF1), a transcriptional target of p53, and that both p21 and p53 bind to Slug, which promotes cell invasion. Functional st...
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| Izdano u: | EMBO Rep |
|---|---|
| Glavni autori: | , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Blackwell Publishing Ltd
2014
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4253846/ https://ncbi.nlm.nih.gov/pubmed/25141863 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201438587 |
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