Cooperative actions of p21(WAF)(1) and p53 induce Slug protein degradation and suppress cell invasion

How the p53 transcription factor/tumor suppressor inhibits cell invasion is poorly understood. We demonstrate that this function of p53 requires its direct interaction with p21(WAF1), a transcriptional target of p53, and that both p21 and p53 bind to Slug, which promotes cell invasion. Functional st...

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Detalhes bibliográficos
Publicado no:EMBO Rep
Main Authors: Kim, Jongdoo, Bae, Seunghee, An, Sungkwan, Park, Jong Kuk, Kim, Eun Mi, Hwang, Sang-Gu, Kim, Wun-Jae, Um, Hong-Duck
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2014
Assuntos:
Scientific Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4253846/
https://ncbi.nlm.nih.gov/pubmed/25141863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201438587
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