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Slug promotes p53 and p21 protein degradation by inducing Mdm2 expression in HCT116 colon cancer cells
Our previous study revealed that the tumor suppressor/transcription factor p53 directly binds to its transcriptional target, p21, and that the p53/p21 complex binds to zinc finger protein SNAI2 (Slug), a tumor promoter/transcription factor; thereby promoting the degradation of Slug by Mdm2, an E3 li...
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| Publicado no: | Oncol Lett |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
D.A. Spandidos
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8323001/ https://ncbi.nlm.nih.gov/pubmed/34345306 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ol.2021.12942 |
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