Nuclear and cytoplasmic p53 suppress cell invasion by inhibiting respiratory Complex-I activity via Bcl-2 family proteins

Although the p53 tumor suppressor/transcription factor often accumulates in the cytoplasm of healthy cells, limited information is available on the cytoplasmic function of p53. Here, we show that cytoplasmic p53 suppresses cell invasion by reducing mitochondrial reactive oxygen species (ROS) levels....

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Kim, Eun Mi, Park, Jong Kuk, Hwang, Sang-Gu, Kim, Wun-Jae, Liu, Zheng-Gang, Kang, Sang Won, Um, Hong-Duck
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2014
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4226696/
https://ncbi.nlm.nih.gov/pubmed/25115399
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