DNA immunization site determines the level of gene expression and the magnitude, but not the type of the induced immune response

Optimization of DNA vaccine delivery improves the potency of the immune response and is crucial to clinical success. Here, we inquired how such optimization impacts the magnitude of the response, its specificity and type. BALB/c mice were DNA-immunized with two model immunogens, HIV-1 protease and r...

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Publicado en:PLoS One
Autores principales: Petkov, Stefan, Starodubova, Elizaveta, Latanova, Anastasia, Kilpeläinen, Athina, Latyshev, Oleg, Svirskis, Simons, Wahren, Britta, Chiodi, Francesca, Gordeychuk, Ilya, Isaguliants, Maria
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5986124/
https://ncbi.nlm.nih.gov/pubmed/29864114
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0197902
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