DNA immunization site determines the level of gene expression and the magnitude, but not the type of the induced immune response

Optimization of DNA vaccine delivery improves the potency of the immune response and is crucial to clinical success. Here, we inquired how such optimization impacts the magnitude of the response, its specificity and type. BALB/c mice were DNA-immunized with two model immunogens, HIV-1 protease and r...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Petkov, Stefan, Starodubova, Elizaveta, Latanova, Anastasia, Kilpeläinen, Athina, Latyshev, Oleg, Svirskis, Simons, Wahren, Britta, Chiodi, Francesca, Gordeychuk, Ilya, Isaguliants, Maria
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5986124/
https://ncbi.nlm.nih.gov/pubmed/29864114
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0197902
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