Fusion to Flaviviral Leader Peptide Targets HIV-1 Reverse Transcriptase for Secretion and Reduces Its Enzymatic Activity and Ability to Induce Oxidative Stress but Has No Major Effects on Its Immunogenic Performance in DNA-Immunized Mice

Reverse transcriptase (RT) is a key enzyme in viral replication and susceptibility to ART and a crucial target of immunotherapy against drug-resistant HIV-1. RT induces oxidative stress which undermines the attempts to make it immunogenic. We hypothesized that artificial secretion may reduce the str...

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Dettagli Bibliografici
Pubblicato in:J Immunol Res
Autori principali: Latanova, Anastasia, Petkov, Stefan, Kuzmenko, Yulia, Kilpeläinen, Athina, Ivanov, Alexander, Smirnova, Olga, Krotova, Olga, Korolev, Sergey, Hinkula, Jorma, Karpov, Vadim, Isaguliants, Maria, Starodubova, Elizaveta
Natura: Artigo
Lingua:Inglês
Pubblicazione: Hindawi 2017
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5498913/
https://ncbi.nlm.nih.gov/pubmed/28717654
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2017/7407136
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