Degradation of brown adipocyte purine nucleotides regulates uncoupling protein 1 activity

OBJECTIVE: Non-shivering thermogenesis in mammalian brown adipose tissue depends on thermogenic uncoupling protein 1. Its activity is triggered by free fatty acids while purine nucleotides mediate inhibition. During activation, it is thought that free fatty acids overcome purine-mediated inhibition....

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Dettagli Bibliografici
Pubblicato in:Mol Metab
Autori principali: Fromme, Tobias, Kleigrewe, Karin, Dunkel, Andreas, Retzler, Angelika, Li, Yongguo, Maurer, Stefanie, Fischer, Natascha, Diezko, Rolf, Kanzleiter, Timo, Hirschberg, Verena, Hofmann, Thomas, Klingenspor, Martin
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2017
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5985227/
https://ncbi.nlm.nih.gov/pubmed/29310935
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2017.12.010
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