Degradation of brown adipocyte purine nucleotides regulates uncoupling protein 1 activity

OBJECTIVE: Non-shivering thermogenesis in mammalian brown adipose tissue depends on thermogenic uncoupling protein 1. Its activity is triggered by free fatty acids while purine nucleotides mediate inhibition. During activation, it is thought that free fatty acids overcome purine-mediated inhibition....

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Vydáno v:Mol Metab
Hlavní autoři: Fromme, Tobias, Kleigrewe, Karin, Dunkel, Andreas, Retzler, Angelika, Li, Yongguo, Maurer, Stefanie, Fischer, Natascha, Diezko, Rolf, Kanzleiter, Timo, Hirschberg, Verena, Hofmann, Thomas, Klingenspor, Martin
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier 2017
Témata:
Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5985227/
https://ncbi.nlm.nih.gov/pubmed/29310935
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2017.12.010
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