Degradation of brown adipocyte purine nucleotides regulates uncoupling protein 1 activity

OBJECTIVE: Non-shivering thermogenesis in mammalian brown adipose tissue depends on thermogenic uncoupling protein 1. Its activity is triggered by free fatty acids while purine nucleotides mediate inhibition. During activation, it is thought that free fatty acids overcome purine-mediated inhibition....

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Detalhes bibliográficos
Publicado no:Mol Metab
Main Authors: Fromme, Tobias, Kleigrewe, Karin, Dunkel, Andreas, Retzler, Angelika, Li, Yongguo, Maurer, Stefanie, Fischer, Natascha, Diezko, Rolf, Kanzleiter, Timo, Hirschberg, Verena, Hofmann, Thomas, Klingenspor, Martin
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2017
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5985227/
https://ncbi.nlm.nih.gov/pubmed/29310935
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2017.12.010
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