Degradation of brown adipocyte purine nucleotides regulates uncoupling protein 1 activity

OBJECTIVE: Non-shivering thermogenesis in mammalian brown adipose tissue depends on thermogenic uncoupling protein 1. Its activity is triggered by free fatty acids while purine nucleotides mediate inhibition. During activation, it is thought that free fatty acids overcome purine-mediated inhibition....

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Publicat a:Mol Metab
Autors principals: Fromme, Tobias, Kleigrewe, Karin, Dunkel, Andreas, Retzler, Angelika, Li, Yongguo, Maurer, Stefanie, Fischer, Natascha, Diezko, Rolf, Kanzleiter, Timo, Hirschberg, Verena, Hofmann, Thomas, Klingenspor, Martin
Format: Artigo
Idioma:Inglês
Publicat: Elsevier 2017
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5985227/
https://ncbi.nlm.nih.gov/pubmed/29310935
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2017.12.010
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