Aspartate beta-hydroxylase promotes cholangiocarcinoma progression by modulating RB1 phosphorylation

Cholangiocarcinoma (CCA) is a highly lethal and aggressive disease. Recently, IDH1/2 mutations have been identified in approximately 20% of CCAs which suggests an involvement of 2-oxoglutarate (2-OG) -dependent dioxygenases in oncogenesis. We investigated if the 2-OG dependent dioxygenase, aspartate...

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Publicado en:Cancer Lett
Autores principales: Huang, Chiung-Kuei, Iwagami, Yoshifumi, Zou, Jing, Casulli, Sarah, Lu, Shaolei, Nagaoka, Katsuya, Ji, Chengcheng, Ogawa, Kousuke, Cao, Kevin Y., Gao, Jin-Song, Carlson, Rolf I., Wands, Jack R.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2018
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5985220/
https://ncbi.nlm.nih.gov/pubmed/29733964
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.canlet.2018.04.041
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