Anti-tumor activity of antibody drug conjugate targeting aspartate-β-hydroxylase in pancreatic ductal adenocarcinoma

Pancreatic ductal adenocarcinoma (PDAC) is an extremely aggressive malignancy with very limited treatment options. Antibody drug conjugates (ADCs) are promising cytotoxic agents capable of highly selective delivery. Aspartate-β-hydroxylase (ASPH) is a type II transmembrane protein highly expressed i...

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Udgivet i:Cancer Lett
Main Authors: Nagaoka, Katsuya, Bai, Xuewei, Ogawa, Kosuke, Dong, Xiaoqun, Zhang, Songhua, Zhou, Yanmei, Carlson, Rolf I., Jiang, Zhi-Gang, Fuller, Steve, Lebowitz, Michael S., Ghanbari, Hossein, Wands, Jack R.
Format: Artigo
Sprog:Inglês
Udgivet: 2019
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6411448/
https://ncbi.nlm.nih.gov/pubmed/30768955
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.canlet.2019.02.006
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