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Anti-tumor activity of antibody drug conjugate targeting aspartate-β-hydroxylase in pancreatic ductal adenocarcinoma

Pancreatic ductal adenocarcinoma (PDAC) is an extremely aggressive malignancy with very limited treatment options. Antibody drug conjugates (ADCs) are promising cytotoxic agents capable of highly selective delivery. Aspartate-β-hydroxylase (ASPH) is a type II transmembrane protein highly expressed i...

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Detalhes bibliográficos
Publicado no:Cancer Lett
Main Authors: Nagaoka, Katsuya, Bai, Xuewei, Ogawa, Kosuke, Dong, Xiaoqun, Zhang, Songhua, Zhou, Yanmei, Carlson, Rolf I., Jiang, Zhi-Gang, Fuller, Steve, Lebowitz, Michael S., Ghanbari, Hossein, Wands, Jack R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6411448/
https://ncbi.nlm.nih.gov/pubmed/30768955
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.canlet.2019.02.006
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