Circadian clock component REV-ERBα controls homeostatic regulation of pulmonary inflammation

Recent studies reveal that airway epithelial cells are critical pulmonary circadian pacemaker cells, mediating rhythmic inflammatory responses. Using mouse models, we now identify the rhythmic circadian repressor REV-ERBα as essential to the mechanism coupling the pulmonary clock to innate immunity,...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Pariollaud, Marie, Gibbs, Julie E., Hopwood, Thomas W., Brown, Sheila, Begley, Nicola, Vonslow, Ryan, Poolman, Toryn, Guo, Baoqiang, Saer, Ben, Jones, D. Heulyn, Tellam, James P., Bresciani, Stefano, Tomkinson, Nicholas C.O., Wojno-Picon, Justyna, Cooper, Anthony W.J., Daniels, Dion A., Trump, Ryan P., Grant, Daniel, Zuercher, William, Willson, Timothy M., MacDonald, Andrew S., Bolognese, Brian, Podolin, Patricia L., Sanchez, Yolanda, Loudon, Andrew S.I., Ray, David W.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5983347/
https://ncbi.nlm.nih.gov/pubmed/29533925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI93910
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