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Proteomic method identifies proteins nitrated in vivo during inflammatory challenge

Inflammation in asthma, sepsis, transplant rejection, and many neurodegenerative diseases associates an up-regulation of NO synthesis with increased protein nitration at tyrosine. Nitration can cause protein dysfunction and is implicated in pathogenesis, but few proteins that appear nitrated in vivo...

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Detalhes bibliográficos
Main Authors: Aulak, Kulwant S., Miyagi, Masaru, Yan, Lin, West, Karen A., Massillon, Duna, Crabb, John W., Stuehr, Dennis J.
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 2001
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC59826/
https://ncbi.nlm.nih.gov/pubmed/11593016
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.221269198
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