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Cosolutes, Crowding, and Protein Folding Kinetics

Long accepted as the most important interaction, recent work shows that steric repulsions alone cannot explain the effects of macromolecular cosolutes on the equilibrium thermodynamics of protein stability. Instead, chemical interactions have been shown to modulate, and even dominate, crowding-induc...

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Detalhes bibliográficos
Publicado no:J Phys Chem B
Main Authors: Gorensek-Benitez, Annelise H., Smith, Austin E., Stadmiller, Samantha S., Perez Goncalves, Gerardo M., Pielak, Gary J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5982521/
https://ncbi.nlm.nih.gov/pubmed/28605189
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jpcb.7b03786
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