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Molecular recognition of RAS/RAF complex at the membrane: Role of RAF cysteine-rich domain

Activation of RAF kinase involves the association of its RAS-binding domain (RBD) and cysteine-rich domain (CRD) with membrane-anchored RAS. However, the overall architecture of the RAS/RBD/CRD ternary complex and the orientations of its constituent domains at the membrane remain unclear. Here, we h...

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Dettagli Bibliografici
Pubblicato in:Sci Rep
Autori principali: Travers, Timothy, López, Cesar A., Van, Que N., Neale, Chris, Tonelli, Marco, Stephen, Andrew G., Gnanakaran, S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2018
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5981303/
https://ncbi.nlm.nih.gov/pubmed/29855542
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-26832-4
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