OGT (O-GlcNAc Transferase) Selectively Modifies Multiple Residues Unique to Lamin A

The LMNA gene encodes lamins A and C with key roles in nuclear structure, signaling, gene regulation, and genome integrity. Mutations in LMNA cause over 12 diseases (‘laminopathies’). Lamins A and C are identical for their first 566 residues. However, they form separate filaments in vivo, with appar...

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Detalhes bibliográficos
Publicado no:Cells
Main Authors: Simon, Dan N., Wriston, Amanda, Fan, Qiong, Shabanowitz, Jeffrey, Florwick, Alyssa, Dharmaraj, Tejas, Peterson, Sherket B., Gruenbaum, Yosef, Carlson, Cathrine R., Grønning-Wang, Line M., Hunt, Donald F., Wilson, Katherine L.
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5981268/
https://ncbi.nlm.nih.gov/pubmed/29772801
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells7050044
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