A Phage Lysin Fused to a Cell-Penetrating Peptide Kills Intracellular Methicillin-Resistant Staphylococcus aureus in Keratinocytes and Has Potential as a Treatment for Skin Infections in Mice

Staphylococcus aureus is the main pathogen that causes skin and skin structure infections and is able to survive and persist in keratinocytes of the epidermis. Since the evolution of multidrug-resistant bacteria, the use of phages and their lysins has presented a promising alternative approach to tr...

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Bibliographische Detailangaben
Veröffentlicht in:Appl Environ Microbiol
Hauptverfasser: Wang, ZhaoFei, Kong, LiCheng, Liu, Yang, Fu, Qiang, Cui, ZeLin, Wang, Jian, Ma, JingJiao, Wang, HengAn, Yan, YaXian, Sun, JianHe
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2018
Schlagworte:
Enzymology and Protein Engineering
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5981068/
https://ncbi.nlm.nih.gov/pubmed/29625989
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AEM.00380-18
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