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Outside‐In Systems Pharmacology Combines Innovative Computational Methods With High‐Throughput Whole Vertebrate Studies

To advance the systems approach in pharmacology, experimental models and computational methods need to be integrated from early drug discovery onward. Here, we propose outside‐in model development, a model identification technique to understand and predict the dynamics of a system without requiring...

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Detalles Bibliográficos
Publicado en:CPT Pharmacometrics Syst Pharmacol
Main Authors: Schulthess, Pascal, van Wijk, Rob C., Krekels, Elke H. J., Yates, James W. T., Spaink, Herman P., van der Graaf, Piet H.
Formato: Artigo
Idioma:Inglês
Publicado: John Wiley and Sons Inc. 2018
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5980533/
https://ncbi.nlm.nih.gov/pubmed/29693322
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/psp4.12297
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