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Outside‐In Systems Pharmacology Combines Innovative Computational Methods With High‐Throughput Whole Vertebrate Studies

To advance the systems approach in pharmacology, experimental models and computational methods need to be integrated from early drug discovery onward. Here, we propose outside‐in model development, a model identification technique to understand and predict the dynamics of a system without requiring...

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Detalhes bibliográficos
Publicado no:CPT Pharmacometrics Syst Pharmacol
Main Authors: Schulthess, Pascal, van Wijk, Rob C., Krekels, Elke H. J., Yates, James W. T., Spaink, Herman P., van der Graaf, Piet H.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5980533/
https://ncbi.nlm.nih.gov/pubmed/29693322
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/psp4.12297
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