Spermidine promotes nucleus pulposus autophagy as a protective mechanism against apoptosis and ameliorates disc degeneration

Spermidine has therapeutic effects in many diseases including as heart diastolic function, myopathic defects and neurodegenerative disorders via autophagy activation. Autophagy has been found to mitigate cell apoptosis in intervertebral disc degeneration (IDD). Accordingly, we theorize that spermidi...

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Pubblicato in:J Cell Mol Med
Autori principali: Zheng, Zengming, Wang, Zhou‐Guang, Chen, Yu, Chen, Jian, Khor, Sinan, Li, Jiawei, He, Zili, Wang, Qingqing, Zhang, Hongyu, Xu, Ke, Fanghua, Gong, Xiao, Jian, Wang, Xiangyang
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2018
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Original Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5980193/
https://ncbi.nlm.nih.gov/pubmed/29575654
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jcmm.13586
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