CRISPR/Cas9-Based Cellular Engineering for Targeted Gene Overexpression

Gene and cellular therapies hold tremendous promise as agents for treating genetic disorders. However, the effective delivery of genes, particularly large ones, and expression at therapeutic levels can be challenging in cells of clinical relevance. To address this engineering hurdle, we sought to em...

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Detalhes bibliográficos
Publicado no:Int J Mol Sci
Main Authors: Osborn, Mark J., Lees, Christopher J., McElroy, Amber N., Merkel, Sarah C., Eide, Cindy R., Mathews, Wendy, Feser, Colby J., Tschann, Madison, McElmury, Ron T., Webber, Beau R., Kim, Chong Jai, Blazar, Bruce R., Tolar, Jakub
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5979553/
https://ncbi.nlm.nih.gov/pubmed/29565806
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms19040946
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