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Real‐time observation of flexible domain movements in CRISPR–Cas9
The CRISPR‐associated protein Cas9 is widely used for genome editing because it cleaves target DNA through the assistance of a single‐guide RNA (sgRNA). Structural studies have revealed the multi‐domain architecture of Cas9 and suggested sequential domain movements of Cas9 upon binding to the sgRNA...
Uloženo v:
| Vydáno v: | EMBO J |
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| Hlavní autoři: | , , , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
John Wiley and Sons Inc.
2018
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5978321/ https://ncbi.nlm.nih.gov/pubmed/29650679 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201796941 |
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