Mutation of CD2AP and SH3KBP1 Binding Motif in Alphavirus nsP3 Hypervariable Domain Results in Attenuated Virus

Infection by Chikungunya virus (CHIKV) of the Old World alphaviruses (family Togaviridae) in humans can cause arthritis and arthralgia. The virus encodes four non-structural proteins (nsP) (nsP1, nsp2, nsP3 and nsP4) that act as subunits of the virus replicase. These proteins also interact with nume...

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Vydáno v:Viruses
Hlavní autoři: Mutso, Margit, Morro, Ainhoa Moliner, Smedberg, Cecilia, Kasvandik, Sergo, Aquilimeba, Muriel, Teppor, Mona, Tarve, Liisi, Lulla, Aleksei, Lulla, Valeria, Saul, Sirle, Thaa, Bastian, McInerney, Gerald M, Merits, Andres, Varjak, Margus
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5977219/
https://ncbi.nlm.nih.gov/pubmed/29702546
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/v10050226
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