Mutation of CD2AP and SH3KBP1 Binding Motif in Alphavirus nsP3 Hypervariable Domain Results in Attenuated Virus

Infection by Chikungunya virus (CHIKV) of the Old World alphaviruses (family Togaviridae) in humans can cause arthritis and arthralgia. The virus encodes four non-structural proteins (nsP) (nsP1, nsp2, nsP3 and nsP4) that act as subunits of the virus replicase. These proteins also interact with nume...

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Publicado no:Viruses
Main Authors: Mutso, Margit, Morro, Ainhoa Moliner, Smedberg, Cecilia, Kasvandik, Sergo, Aquilimeba, Muriel, Teppor, Mona, Tarve, Liisi, Lulla, Aleksei, Lulla, Valeria, Saul, Sirle, Thaa, Bastian, McInerney, Gerald M, Merits, Andres, Varjak, Margus
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5977219/
https://ncbi.nlm.nih.gov/pubmed/29702546
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/v10050226
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