AZD1775 Increases Sensitivity to Olaparib and Gemcitabine in Cancer Cells with p53 Mutations

Tumor suppressor p53 is responsible for enforcing cell cycle checkpoints at G1/S and G2/M in response to DNA damage, thereby allowing both normal and tumor cells to repair DNA before entering S and M. However, tumor cells with absent or mutated p53 are able to activate alternative signaling pathways...

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Detalhes bibliográficos
Publicado no:Cancers (Basel)
Main Authors: Meng, Xiangbing, Bi, Jianling, Li, Yujun, Yang, Shujie, Zhang, Yuping, Li, Mary, Liu, Haitao, Li, Yiyang, Mcdonald, Megan E., Thiel, Kristina W., Wen, Kuo-Kuang, Wang, Xinhao, Wu, Meng, Leslie, Kimberly K.
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5977122/
https://ncbi.nlm.nih.gov/pubmed/29783721
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers10050149
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