Combination of Proteasome and Histone Deacetylase Inhibitors Overcomes the Impact of Gain-of-Function p53 Mutations

Mutations in the “guardian of the genome” TP53 predominate in solid tumors. In addition to loss of tumor suppressor activity, a specific subset of missense mutations confers additional oncogenic properties. These “gain-of-function” (GOF) mutations portend poor prognosis across cancer types regardles...

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Bibliographic Details
Published in:Dis Markers
Main Authors: Meng, Xiangbing, Yang, Shujie, Li, Yujun, Li, Yiyang, Devor, Eric J., Bi, Jianling, Wang, Xinhao, Umesalma, Shaikamjad, Quelle, Dawn E., Thiel, William H., Thiel, Kristina W., Leslie, Kimberly K.
Format: Artigo
Language:Inglês
Published: Hindawi 2018
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6311857/
https://ncbi.nlm.nih.gov/pubmed/30647797
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2018/3810108
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