A New Strategy to Control and Eradicate “Undruggable” Oncogenic K-RAS-Driven Pancreatic Cancer: Molecular Insights and Core Principles Learned from Developmental and Evolutionary Biology

Oncogenic K-RAS mutations are found in virtually all pancreatic cancers, making K-RAS one of the most targeted oncoproteins for drug development in cancer therapies. Despite intense research efforts over the past three decades, oncogenic K-RAS has remained largely “undruggable”. Rather than targetin...

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Detalhes bibliográficos
Publicado no:Cancers (Basel)
Main Authors: Van Sciver, Robert E., Lee, Michael P., Lee, Caroline Dasom, Lafever, Alex C., Svyatova, Elizaveta, Kanda, Kevin, Collier, Amber L., Siewertsz van Reesema, Lauren L., Tang-Tan, Angela M., Zheleva, Vasilena, Bwayi, Monicah N., Bian, Minglei, Schmidt, Rebecca L., Matrisian, Lynn M., Petersen, Gloria M., Tang, Amy H.
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2018
Assuntos:
Review
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5977115/
https://ncbi.nlm.nih.gov/pubmed/29757973
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers10050142
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