A New Strategy to Control and Eradicate “Undruggable” Oncogenic K-RAS-Driven Pancreatic Cancer: Molecular Insights and Core Principles Learned from Developmental and Evolutionary Biology

Oncogenic K-RAS mutations are found in virtually all pancreatic cancers, making K-RAS one of the most targeted oncoproteins for drug development in cancer therapies. Despite intense research efforts over the past three decades, oncogenic K-RAS has remained largely “undruggable”. Rather than targetin...

Полное описание

Сохранить в:
Библиографические подробности
Опубликовано в: :Cancers (Basel)
Главные авторы: Van Sciver, Robert E., Lee, Michael P., Lee, Caroline Dasom, Lafever, Alex C., Svyatova, Elizaveta, Kanda, Kevin, Collier, Amber L., Siewertsz van Reesema, Lauren L., Tang-Tan, Angela M., Zheleva, Vasilena, Bwayi, Monicah N., Bian, Minglei, Schmidt, Rebecca L., Matrisian, Lynn M., Petersen, Gloria M., Tang, Amy H.
Формат: Artigo
Язык:Inglês
Опубликовано: MDPI 2018
Предметы:
Review
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5977115/
https://ncbi.nlm.nih.gov/pubmed/29757973
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers10050142
Метки: Добавить метку
Нет меток, Требуется 1-ая метка записи!

Схожие документы