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Structure–Activity Relationships of 8-Styrylxanthines as A(2)-Selective Adenosine Antagonists(,)

A series of substituted 8-styryl derivatives of 1,3,7-alkylxanthines was synthesized as potential A(2)-selective adenosine receptor antagonists, and the potency at rat brain A(1)- and A(2)-receptors was studied in radioligand binding experiments. At the xanthine 7-position, only small hydrophobic su...

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Vydáno v:J Med Chem
Hlavní autoři: Jacobson, Kenneth A., Gallo-Rodriguez, Carola, Melman, Neli, Fischer, Bilha, Maillard, Michel, van Bergen, Andrew, van Galen, Philip J. M., Karton, Yishai
Médium: Artigo
Jazyk:Inglês
Vydáno: 1993
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5975975/
https://ncbi.nlm.nih.gov/pubmed/8496902
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