Prediction of Drug-Induced Hepatotoxicity Using Long-Term Stable Primary Hepatic 3D Spheroid Cultures in Chemically Defined Conditions

High failure rates of drug candidates in the clinics, restricted-use warnings as well as withdrawals of drugs in postmarketing stages are of substantial concern for the pharmaceutical industry and drug-induced liver injury (DILI) constitutes one of the most frequent reasons for such safety failures....

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Toxicol Sci
Hlavní autoři: Vorrink, Sabine U, Zhou, Yitian, Ingelman-Sundberg, Magnus, Lauschke, Volker M
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2018
Témata:
3d Hepatic Spheroid Cultures for Predicting Toxicity
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5974779/
https://ncbi.nlm.nih.gov/pubmed/29590495
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfy058
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky