Endogenous and xenobiotic metabolic stability of primary human hepatocytes in long-term 3D spheroid cultures revealed by a combination of targeted and untargeted metabolomics

Adverse reactions or lack of response to medications are important concerns for drug development programs. However, faithful predictions of drug metabolism and toxicity are difficult because animal models show only limited translatability to humans. Furthermore, current in vitro systems, such as hep...

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Detalhes bibliográficos
Publicado no:FASEB J
Main Authors: Vorrink, Sabine U., Ullah, Shahid, Schmidt, Staffan, Nandania, Jatin, Velagapudi, Vidya, Beck, Olof, Ingelman-Sundberg, Magnus, Lauschke, Volker M.
Formato: Artigo
Idioma:Inglês
Publicado em: Federation of American Societies for Experimental Biology 2017
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5434660/
https://ncbi.nlm.nih.gov/pubmed/28264975
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201601375R
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