Blockade of MIF–CD74 Signalling on Macrophages and Dendritic Cells Restores the Antitumour Immune Response Against Metastatic Melanoma

Mounting an effective immune response against cancer requires the activation of innate and adaptive immune cells. Metastatic melanoma is the most aggressive form of skin cancer. While immunotherapies have shown a remarkable success in melanoma treatment, patients develop resistance by mechanisms tha...

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Bibliographic Details
Published in:Front Immunol
Main Authors: Figueiredo, Carlos R., Azevedo, Ricardo A., Mousdell, Sasha, Resende-Lara, Pedro T., Ireland, Lucy, Santos, Almudena, Girola, Natalia, Cunha, Rodrigo L. O. R., Schmid, Michael C., Polonelli, Luciano, Travassos, Luiz R., Mielgo, Ainhoa
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2018
Subjects:
Immunology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5974174/
https://ncbi.nlm.nih.gov/pubmed/29875777
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.01132
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