Mlh1 deficiency in normal mouse colon mucosa associates with chromosomally unstable colon cancer

Colorectal cancer (CRC) genome is unstable and different types of instabilities, such as chromosomal instability (CIN) and microsatellite instability (MSI) are thought to reflect distinct cancer initiating mechanisms. Although 85% of sporadic CRC reveal CIN, 15% reveal mismatch repair (MMR) malfunct...

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Detalles Bibliográficos
Publicado en:Carcinogenesis
Main Authors: Pussila, Marjaana, Törönen, Petri, Einarsdottir, Elisabet, Katayama, Shintaro, Krjutškov, Kaarel, Holm, Liisa, Kere, Juha, Peltomäki, Päivi, Mäkinen, Markus J, Linden, Jere, Nyström, Minna
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2018
Assuntos:
Cancer Biomarkers and Molecular Epidemiology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5973430/
https://ncbi.nlm.nih.gov/pubmed/29701748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgy056
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