Pleomorphic Adenoma Gene 1 Is Needed For Timely Zygotic Genome Activation and Early Embryo Development

Pleomorphic adenoma gene 1 (PLAG1) is a transcription factor involved in cancer and growth. We discovered a de novo DNA motif containing a PLAG1 binding site in the promoters of genes activated during zygotic genome activation (ZGA) in human embryos. This motif was located within an Alu element in a...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Madissoon, Elo, Damdimopoulos, Anastasios, Katayama, Shintaro, Krjutškov, Kaarel, Einarsdottir, Elisabet, Mamia, Katariina, De Groef, Bert, Hovatta, Outi, Kere, Juha, Damdimopoulou, Pauliina
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6557853/
https://ncbi.nlm.nih.gov/pubmed/31182756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-44882-0
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