Lipodystrophic syndromes due to LMNA mutations: recent developments on biomolecular aspects, pathophysiological hypotheses and therapeutic perspectives

Mutations in LMNA, encoding A-type lamins, are responsible for laminopathies including muscular dystrophies, lipodystrophies, and premature ageing syndromes. LMNA mutations have been shown to alter nuclear structure and stiffness, binding to partners at the nuclear envelope or within the nucleoplasm...

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Bibliografiska uppgifter
I publikationen:Nucleus
Huvudupphovsmän: Vigouroux, Corinne, Guénantin, Anne-Claire, Vatier, Camille, Capel, Emilie, Le Dour, Caroline, Afonso, Pauline, Bidault, Guillaume, Béréziat, Véronique, Lascols, Olivier, Capeau, Jacqueline, Briand, Nolwenn, Jéru, Isabelle
Materialtyp: Artigo
Språk:Inglês
Publicerad: Taylor & Francis 2018
Ämnen:
Laminopathies
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5973242/
https://ncbi.nlm.nih.gov/pubmed/29578370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19491034.2018.1456217
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