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Expanded base editing in rice and wheat using a Cas9-adenosine deaminase fusion
Nucleotide base editors in plants have been limited to conversion of cytosine to thymine. Here, we describe a new plant adenine base editor based on an evolved tRNA adenosine deaminase fused to the nickase CRISPR/Cas9, enabling A•T to G•C conversion at frequencies up to 7.5% in protoplasts and 59.1%...
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| Publicado no: | Genome Biol |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5972399/ https://ncbi.nlm.nih.gov/pubmed/29807545 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-018-1443-z |
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